Formulation and evaluation of alfuzosin hydrochloride extended release tablets
Purpose The aim of the study was to design extended release tablets capable of producing a 20 h extended release profile there by eliminating the use of immediate release tablets which require a frequent administration of three tablets containing 2.5 mg of alfuzosin hydrochloride of daily dose. The present study deals with formulation of Alfuzosin Hydrochloride extended release tablets. Benign prostatic hyperplasia is a noncancerous prostate problem in which the normal elements of the prostate gland grow in size and number, requires an alpha-adrenergic blocker which is having optimum therapeutic window concentration for a prolonged duration. With the above characteristics Alfuzosin Hydrochloride was selected as active therapeutic agent. Methods. Alfuzosin HCl extended release matrix tablets were prepared by direct compression method by employing hydrophilic polymer HPMC K 100 M and Crosslinked xyloglucan (XG).The crosslinked XG was prepared by crosslinking of natural polysaccharide i.e XG with crosslinking agent Sodium trimetaphosphate (STMP). Simplex centroid design was applied for the optimization process. The prepared tablets were evaluated for various physicochemical parameters by official procedures. The in-vitro release study of matrix tablets was carried out in 0.01N HCl for 24 hours. Results. The tablets exhibited acceptable physicochemical characteristics and extended drug release pattern was observed for about 20h. Analysis of drug release data from the matrix system indicated that the drug release follows zero order kinetics by anomalous (non-fickian) diffusion. Conclusion. The crosslinked XG alongwith HPMC K 100M & DCP showed the potential for prolonged delivery of Alfuzosin over a 20 h period and therefore may be a suitable candidate for use in sustained release drug delivery system.
Published by: Pradnya Zine, Dr. Ashwini Madgulkar, Dr. Mangesh Bhalekar
Author: Pradnya Zine
Paper ID: V5I3-1866
Paper Status: published
Published: June 17, 2019
Availability of physical and infrastructure resources facilitating agricultural commodity trading in north Karnataka
Today in current scenario agriculture markets are the hub of the rural economy. Agricultural marketing today means more than linking the producer with the consumer, it includes the creation of a favorable economic environment for farmers to enthuse them to grow more and get proceeds from transactions. Many alternative forms, such as cooperative marketing, group marketing, contract marketing, futures trading, direct marketing, and e-commerce are in vogue. Agricultural produce markets are nerve centers from where marketing impulses are transmitted to put all the marketing activity on track and safeguard the interest of both farmers and consumers. Finally efforts should be made in terms of setting up proper marketing infrastructure that will facilitate the market participants to carry out the trading activities and also provide awareness, training, practical experiences, support needed to small, marginal and medium farmers at village/rural areas in terms of newer ways of agriculture marketing channels so that every farmer will be able to adopt better marketing techniques like common online platforms for selling their produce and get the remunerative prices for the same.
Published by: Sharanabasappa C. B.
Author: Sharanabasappa C. B.
Paper ID: V5I3-1889
Paper Status: published
Published: June 17, 2019
Expense based performance assessment of financial institution
Performance of Financial Institutions is dependent on various aspects that can affect their growth. Many of them are standardized aspects such as Portfolio At Risk, Provision Expense Ratio, Risk Coverage Ratio, Write Off Ratio. Along with these, we introduce a scientific cost distribution value that we name as the Expense Accrual Ratio (EAR). Along with the other parameters of measurement, EAR can be used to assess if the health of a financial institution. In this paper, we explain the role and functioning of EAR along with ways of calculation of it with formulas for the derivation. The effect of dependent parameters on EAR is explored and the graphs are explained. Further, its impact on performance is analyzed with data references. Comparison is done with the current interest rates of the institution to derive at a conclusion based on EAR. Along with other parameters of the measure this can be used as a powerful tool to adjust the functioning of the financial institution to avoid further losses. The necessity to balance EAR for unforeseen or natural calamities has been pointed out for future work.
Published by: Mohd Saifuddin, Muzameel Ahmed, Reehan Lalkhan
Author: Mohd Saifuddin
Paper ID: V5I3-1867
Paper Status: published
Published: June 17, 2019
Government’s preparedness for disaster management based on Bhopal Gas Tragedy 1984
Disaster management is dealing with and avoiding risks. This involves emergency evacuation, disaster response, supporting and rebuilding society after natural or human-made disasters. During the tragedy Union Carbide India Ltd wasn’t prepared for a quick disaster management. Gas concentration in the areas ranged from 85 to 0.12ppm , people who were in deep sleep got awakened by coughing, severe eye irritation, feeling of suffocation and burning in respiratory tract. Thousands of people had died by the following morning. The problem was made worse by the plant’s location near a densely populated area, non-existent catastrophe plans, shortcomings in health care and socio-economic rehabilitation . Analysis shows that the parties responsible for the magnitude of the disaster are the two owners, Union Carbide Corporation and the Government of India and to some extent, the Government of Madhya Pradesh. From a Union Carbide factory killed a total of 16,000 people and injured half a million, Bhopal has become synonymous symbol with an absence of industrial safety measures.
Published by: Greema Micahel K.
Author: Greema Micahel K.
Paper ID: V5I3-1862
Paper Status: published
Published: June 17, 2019
Experimental study on durability assessment of concrete structures due to various chemical attacks
The strength and durability of concrete after casting changes at variance factors regarding physical and chemical damages. Concrete structures with steel-reinforcement are in a continuous and losing life with corrosiveness that naturally occurs from long-term exposure to an aggressive environment. The concrete structure like dams, canals, bridges which have the influence of water forms various types of chemical reactions which include carbonation attack, sulfate attack, chloride attack, alkali-aggregate reaction, etc. Chemical reactions, either intrinsic or extrinsic, are one of the main reason for concrete’s deterioration. The present dissertation consists of an analysis of the chemical expansive reactions in concrete element, the alkalis aggregate reaction, and the internal sulfuric reaction. During the carbonation process, the fundamental element identified in the concrete microstructure is calcite which comes outs at the surface of concrete structure, in the form of cracks. When carbon dioxide causes by environment come contact into the concrete structure and effect with calcium hydroxide to create calcium carbonate this phenomenon is called as carbonation. Carbonation usually describes by ph value which indicates the depth of reaction in the structure. The depth of carbonation directly affects the life of the structure in the year. Through the years to overcome this problem the solution is being discovered by performing various experiments on Concrete after and before the casting. Which gave us the Chemical test like by increasing the CO2 binding capacity, improving CaO Value and physical tests such as applying an epoxy coating, etc. After all, performing the various types of test for a particular outcome finally check for durability tests for the concrete structure is taking place for better result. There are many of them but in this case, it will be ph indicator, UTM and CTM are being discussed. This project address the study of chemical reaction which is take place on various type of concrete structures and affect the durability and strength of it.
Published by: Venkatesh B. Panmand, Dr. Sanjay Kulkarni
Author: Venkatesh B. Panmand
Paper ID: V5I3-1913
Paper Status: published
Published: June 17, 2019
Performance analysis of flat plate hybrid PV/T solar water collector system
Solar Photovoltaic module converts the light component of solar radiation into electrical output measured in watts and heat part is absorbed by module increasing its operating temperature which reduces the electrical efficiency of the module by 10 to 35%. Hence by using the external cooling system, the module temperature can be reduced to improve electrical power efficiency. This cooling system is called a photovoltaic heat exchanger. The cooling system fitted to the backside of the PV module produces thermal power(in terms of hot water), can be used for low-temperature applications. Combined PV module and heat exchanger generating both electrical and thermal power are called as hybrid Photovoltaic/Thermal (PV/T) solar system. Performance of a direct flow heat exchanger and its effect on the hybrid PV/T system is studied in the current paper. The experimental analysis and results like performance efficiencies of Photovoltaic, thermal and PV/T system at different loading conditions were discussed and evaluated for the latitude of Kalyan, Mumbai. The results at solar radiation of 6.52 kWh/m2/day and water mass flow rate of 0.04 kg/sec through heat exchanger showed improvement in combined PV/T efficiency of 73.7% with PV efficiency of 12.7% and performance ratio of 70.5%.
Published by: Snehal Prabhakar Sonawane, H. B. Chaudhari
Author: Snehal Prabhakar Sonawane
Paper ID: V5I3-1902
Paper Status: published
Published: June 17, 2019
